Cal. Code Regs. tit. 27 § 25705 : Environmental Protection — Office of Environmental Health Hazard Assessment — Safe Drinking Water and Toxic Enforcement Act of 1986 — NO Significant Risk Levels — Specific Regulatory Levels Posing No Significant Risk

(a) Daily exposure to a chemical at a level which does not exceed the level set forth in subsections (b), (c) and (d) for such chemical shall be deemed to pose no significant risk within the meaning of Section 25249.10(c) of the Act.
(b) Levels of exposure deemed to pose no significant risk may be determined by the lead agency based on a risk assessment conducted by the lead agency pursuant to the guidelines set forth in Section 25703, or a risk assessment reviewed by the lead agency and determined to be consistent with the guidelines set forth in Section 25703.
(1) The following levels based on risk assessments conducted or reviewed by the lead agency shall be deemed to pose no significant risk:

Chemical Name Level (micrograms/day)
Acrylonitrile 0.7
Aldrin 0.04
Arsenic 0.06 (inhalation)
Asbestos 100 fibers inhaled/day*
Benz[a]anthracene 0.033 (oral)
Benzene 6.4 (oral)
13 (inhalation)
Benzidine 0.001
Benzo[b]fluoranthene 0.096 (oral)
Benzo[j]fluoranthene 0.11 (oral)
Benzofuran 1.1
Bis(2-chloroethyl)ether 0.3
Bis(chloromethyl)ether 0.02
Bromochloroacetic acid 0.70
Bromodichloroacetic acid 0.95
Bromoethane 96
Bromoform 64
Butylated hydroxyanisole 4000
Cadmium 0.05 (inhalation)
Carbon tetrachloride 5
N-Carboxymethyl-N-nitrosourea 0.70
p-Chloroaniline 1.5
p-chloro-?,?,?-trifluorotolune 23
p-Chloroaniline hydrochloride 1.9
Chloroethane 150
Chlorothalonil 41
Chromium (hexavalent compounds) 0.001 (inhalation)
Chrysene 0.35 (oral)
C.I. Direct Blue 218 50
DDT, DDE and DDD (in combination) 2
7H-Dibenzo[c,g]carbazole 0.0030 (oral)
Dibenzo[a,h]pyrene 0.0054 (oral)
Dibenzo[a,i]pyrene 0.0050 (oral)
1,2-Dibromo-3-chloropropane (DBCP) 0.1
Dibromoacetic acid 2.8
Dichloroacetic acid 17
para-Dichlorobenzene 20
3,3'-Dichlorobenzidine 0.6
Dichloromethane (Methylene chloride) 200 (inhalation)
1,2-Dichloropropane 9.7
1,3-Dichloropropene 3.7 (oral)
3.7 (inhalation)
Dieldrin 0.04
Di(2-ethylhexyl)phthalate (DEHP) 310
Diisononyl phthalate (DINP) 146
3,3'-Dimethoxybenzidine 0.15
3,3'-Dimethoxybenzidine dihydrochloride 0.19
3,3'-Dimethylbenzidine 0.044
3,3'-Dimethlybenzidine dihydrochloride 0.059
1,4-Dioxane 30
Epichlorohydrin 9
Ethylbenzene 54 (inhalation)
41 (oral)
Ethylene dibromide 0.2 (ingestion)
3 (inhalation)
Ethylene dichloride 10
Ethylene oxide 2
Glycidol 0.54
Glyphosate 1100
Hexachlorobenzene 0.4
Hexachlorodibenzodioxin 0.0002
Hexachlorocyclohexane (technical grade) 0.2
Lead 15 (oral)
Lead acetate 23 (oral)
Lead phosphate 58 (oral)
Lead subacetate 41 (oral)
Malathion 180
2-Methylaziridine (propyleneimine) 0.028
5-Methylchrysene 0.0084 (oral)
Methylhydrazine 0.058 (oral)
0.090 (inhalation)
Methylhydrazine sulfate 0.18
4-Methylimidazole 29
5-Morpholinomethyl-3-[(5-nitrofurfurylidene) 0.18
-amino]-2-oxazolidinone
MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2 0.11
(5H)-furanone)
Naphthalene 5.8
Nitromethane 39
N-Nitroso-n-dibutylamine 0.06
N-Nitrosodiethylamine 0.02
N-Nitrosodimethylamine 0.04
N-Nitrosodiphenylamine 80
N-Nitrosodi-n-propylamine 0.1
N-Nitroso-N-ethylurea 0.03
N-Nitroso-N-methylurea 0.006
Phenyl glycidyl ether 5.0
Phenylhydrazine 1.0
Phenylhydrazine hydrochloride 1.4
Polybrominated biphenyls 0.02
Polygeenan 1200
Styrene 27
2,3,7,8-Tetrachlorodibenzo-p-dioxin 0.000005
Tetranitromethane 0.059
Toxaphene 0.6
Trichloroacetic acid 9.9
Trichloroethylene 14 (oral)
50 (inhalation)
2,4,6-Trichlorophenol 10
2,4,6-Trinitrotoluene 8.2
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) 5.4
Urethane 0.7
Vinyl chloride 3
Vinylidene chloride 0.88
2,6-Xylidine 110

__________

*Fibers equal to or greater than 5 micrometers in length and 0.3 micrometers in width, with a length to width ratio of greater than or equal to 3:1 as measured by phase contrast microscopy.

(c) Unless a specific regulatory level for a chemical known to the state to cause cancer has been established in subsection (b), levels of exposure deemed to pose no significant risk may be determined by the lead agency based on state or federal risk assessments.
(1) Any interested party may request the lead agency to reevaluate a level established in this subsection based on scientific considerations that indicate the need for the lead agency to develop its own risk assessment or to conduct a detailed review of the risk assessment used to derive the level in question. Such request shall be made in writing, and shall include a description of the scientific considerations that indicate the need for the lead agency to develop its own risk assessment or to conduct a detailed review of the risk assessment used to derive the level in question. The lead agency may establish a level for the chemical in question in subsection (b) as it deems necessary.
(2) The following levels based on state or federal risk assessments shall be deemed to pose no significant risk:

Chemical Name Level (micrograms/day)
Acetaldehyde 90 (inhalation)
Acrylamide 0.2
Aniline 100
Azobenzene 6
Benzo[a]pyrene 0.06
Benzyl chloride 4
Beryllium oxide 0.1
Beryllium sulfate 0.0002
Bromodichloromethane 5
1,3-Butadiene 0.4
Chlordane 0.5
Chloroform 20 (ingestion)
40 (inhalation)
Coke oven emissions 0.3
DDVP (Dichlorvos) 2
Dichloromethane (Methylene chloride) 50
2,4-Dinitrotoluene 2
Folpet 200
Formaldehyde (gas) 40
Furmecyclox 20
Heptachlor 0.2
Heptachlor epoxide 0.08
Hexachlorocyclohexane
alpha isomer 0.3
beta isomer 0.5
gamma isomer 0.6
Hydrazine 0.04
Hydrazine sulfate 0.2
Imazalil 11
4,4' -Methylene
bis (N,N-dimethyl) benzeneamine 20
Nickel refinery dust 0.8
Nickel subsulfide 0.4
N-Nitrosodiethanolamine 0.3
N-Nitrosomethylethylamine 0.03
N-Nitrosopyrrolidine 0.3
Pentachlorophenol 40
Polychlorinated biphenyls (PCBs) 0.09
Tetrachloroethylene 14

(d) Unless a specific regulatory level has been established for a chemical known to the state to cause cancer in subsection (b) or (c), levels of exposure deemed to pose no significant risk may be determined by the lead agency using an expedited method consistent with the procedures specified in Section 25703.
(1) Any interested party may request the lead agency to reevaluate a level established in this subsection and to consider the adoption, in subsection (c), of a level based on a state or federal risk assessment. Such request shall be made in writing, and shall include a copy of the state or federal risk assessment which the interested party wishes the lead agency to consider as the basis for a level in subsection (c). The lead agency may establish a level in subsection (c) for the chemical in question based on a state or federal risk assessment as it deems necessary.
(2) Any interested party may request the lead agency to reevaluate a level established in this subsection based on scientific considerations that indicate the need for a conventional risk assessment. Such request shall be made in writing, and shall include a description of the scientific considerations that indicate the need for a conventional risk assessment. The lead agency may conduct a conventional risk assessment for the chemical in question, and establish a level in subsection (b) as it deems necessary.
(3) The following levels of exposure based on risk assessments conducted by the lead agency using an expedited method consistent with the procedures specified in Section 25703 shall be deemed to pose no significant risk:

Chemical Name Level (micrograms/day)
A-alpha-C
(2-Amino-9H-pyridol[2,3-b]indole) 2
Acetamide 10
2-Acetylaminofluorene 0.2
Actinomycin D 0.00008
AF-2;[2-(2-furyl)-3(5-nitro-2-furyl)
acrylamide] 3
2-Aminoanthraquinone 20
o-Aminoazotoluene 0.2
4-Aminobiphenyl (4-aminodiphenyl) 0.03
3-Amino-9-ethylcarbazole hydrochloride 9
l-Amino-2-methylanthraquinone 5
2-Amino-5-(5-nitro-2-furyl)
-1,3,4-thiadiazole 0.04
Amitrole 0.7
o-Anisidine 5
o-Anisidine hydrochloride 7
Aramite 20
Auramine 0.8
Azaserine 0.06
Azathioprine 0.4
Benzyl violet 4B 30
beta-Butyrolactone 0.7
Carbazole 4.1
Captafol 5
Captan 300
Chlorambucil 0.002
Chlordecone (Kepone) 0.04
Chlorendic acid 8
Chlorinated paraffins (Average chain
length, C12; approximately 60 percent
chlorine by weight) 8
Chloromethyl methyl ether
(technical grade) 0.3
3-Chloro-2-methylpropene 5
4-Chloro-ortho-phenylenediamine 40
p-Chloro-o-toluidine 3
p-Chloro-o-toluidine hydrochloride 3.3
Chlorozotocin 0.003
C. I. Basic Red 9 monohydrochloride 3
Cinnamyl anthranilate 200
p-Cresidine 5
Cupferron 3
Cyclophosphamide (anhydrous) 1
Cyclophosphamide (hydrated) 1
D&C Red No. 9 100
Dacarbazine 0.01
Daminozide 40
Dantron (Chrysazin;
1,8-Dihydroxyanthraquinone) 9
2,4-Diaminoanisole 30
2,4-Diaminoanisole sulfate 50
4,4'-Diaminodiphenyl ether
(4,4'-Oxydianiline) 5
2,4-Diaminotoluene 0.2
Dibenz[a,h]anthracene 0.2
1,1-Dichloroethane 100
Diethylstilbestrol 0.002
Digylcidyl resorcinol ether (DGRE) 0.4
Dihydrosafrole 20
4-Dimethylaminoazobenzene 0.2
trans-2[Dimethylamino)methylimino]-5-
[2-(5-nitro-2-furyl)vinyl]-
1,3,4-oxadiazole 2
7,12-Dimethylbenz(a)anthracene 0.003
Dimethylcarbamyl chloride 0.05
1,2-Dimethylhydrazine 0.001
Dimethylvinylchloride 20
Direct Black 38 (technical grade) 0.09
Direct Blue 6 (technical grade) 0.09
Direct Brown 95 (technical grade) 0.1
Disperse Blue 1 200
Estradiol 17B 0.02
Ethyl-4,4'-dichlorobenzilate
(chlorobenzilate) 7
Ethylene thiourea 20
Ethyleneimine 0.01
2-(2-Formylhydrazino)-4-(5-nitro-2-
furyl)thiazole 0.3
Glu-P-1 (2-Amino-6-methyldipyrido
[1,2-a:3',2'-d]imidazole 0.1
Glu-P-2 (2-Aminodipyrido[1,2-a:3',
2'-d]imidazole 0.5
Gyromitrin (Acetaldehyde
methylformylhydrazone) 0.07
HC Blue 1 10
Hexachloroethane 20
Hydrazobenzene (1,2-Diphenylhydrazine) 0.8
IQ (2-Amino-3-methylimidazo
[4,5-f]quinoline) 0.5
Isobutyl nitrite 7.4
Lasiocarpine 0.09
Me-A-alpha-C (2-Amino-3-
methyl-9H-pyrido[2,3-b]indole) 0.6
MeIQ (2-Amino-3,4-dimethylimidazo 0.46
[4,5-f]quinoline
MeIQx (2-Amino-3,8-dimethylimidazo 0.41
[4,5-f]quinoxaline
Melphalan 0.005
Methyl carbamate 160
3-Methylcholanthrene 0.03
4,4'-Methylene bis(2-chloroaniline) 0.5
4,4'-Methylene bis(2-methylaniline) 0.8
4,4'-Methylenedianiline 0.4
4,4'-Methylenedianiline dihydrochloride 0.6
Methyl methanesulfonate 7
2-Methyl-1-nitroanthraquinone
(of uncertain purity) 0.2
N-Methyl-N'-nitro-N-nitrosoguanidine 0.08
Methylthiouracil 2
Michler's ketone 0.8
Mirex 0.04
Mitomycin C 0.00009
Monocrotaline 0.07
Nalidixic acid 28
2-Naphthylamine 0.4
Nitrilotriacetic acid 100
Nitrilotriacetic acid, trisodium salt
monohydrate 70
5-Nitroacenaphthene 6
Nitrofen (technical grade) 9
Nitrofurazone 0.5
1-[(5-Nitrofurfurylidine)-amino]-
2-imidazolidinone 0.4
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]
acetamide 0.5
p-Nitrodiphenylamine 30
4-(N-Nitrosomethylamino)-1-(3-pyridyl)- 0.014
1-butanone
N-Nitroso-N-methylurethane 0.006
N-Nitrosomorpholine 0.1
N-Nitrosonornicotine 0.5
N-Nitrosopiperidine 0.07
Phenacetin 300
Phenazopyridine 4
Phenazopyridine hydrochloride 5
Phenesterin 0.005
Phenobarbital 2
Phenoxybenzamine 0.2
Phenoxybenzamine hydrochloride 0.3
o-Phenylenediamine 26
o-Phenylenediamine dihydrochloride 44
o-Phenylphenate, sodium 200
Ponceau MX (D&C Red No. 5) 200
Ponceau 3R (FD&C Red No. 1) 40
Potassium bromate 1
Procarbazine 0.05
Procarbazine hydrochloride 0.06
1,3-Propane sultone 0.3
beta-Propiolactone 0.05
Propylthiouracil 0.7
Reserpine 0.06
Safrole 3
Sterigmatocystin 0.02
Streptozotocin 0.006
Styrene oxide 4
Sulfallate 4
1,1,2,2-Tetrachloroethane 3
Thioacetamide 0.1
4,4'-Thiodianiline 0.05
Thiourea 10
Toluene diisocyanate 20
o-Toluidine 4
o-Toluidine hydrochloride 5
Trimethyl phosphate 24
Tris(1-aziridinyl)phosphine
sulfide (Thiotepa) 0.06
Tris(2,3-dibromopropyl)phosphate 0.3
Trp-P-1 (Tryptophan-P-1) 0.03
Trp-P-2 (Tryptophan-P-2) 0.2
Vinyl trichloride (1,1,2-Trichloroethane) 10

Cal. Code Regs. Tit. 27, § 25705

Note: Authority cited: Section 25249.12, Health and Safety Code. Reference: Sections 25249.5, 25249.6, 25249.9, 25249.10, 25249.11 and 57004, Health and Safety Code.

1. New section filed 2-24-88 as an emergency; operative 2-27-88 (Register 88, No. 11). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 6-27-88.
2. New section refiled 6-27-88 as an emergency; operative 6-27-88 (Register 88, No. 27). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 10-25-88.
3. New section refiled 10-17-88 as an emergency; operative 10-25-88 (Register 88, No. 44). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 2-22-89.
4. New section refiled 2-21-89 as an emergency; operative 2-22-89 (Register 89, No. 10). A Certificate of Compliance must be transmitted to OAL within 120 days or emergency language will be repealed on 6-22-89.
5. Certificate of Compliance including amendment transmitted to OAL 6-9-89 and filed 7-10-89 (Register 89, No. 30).
6. New subsection (b) filed 12-1-89; operative 12-31-89 (Register 89, No. 49).
7. Amendment of subsection (b) filed 5-16-90; operative 6-15-90 (Register 90, No. 25).
8. Amendment of subsection (b) filed 5-24-90; operative 6-23-90 (Register 90, No. 25).
9. Editorial correction of printing error in subsection (b) submitted to OAL for printing only 10-9-90 (Register 91, No. 3).
10. Amendment of subsection (b) adding Benzene filed 11-26-90; operative 12-26-90 (Register 91, No. 3).
11. Amendment of subsection (b) adding Arsenic, Butylated hydroxyanisole, Cadmium, and Chromium filed 9-16-92; operative 10-16-92 (Register 92, No. 38).
12. Amendment of subsection (b) adding Hexachlorodibenzodioxin and 2,3,7,8-Tetrachlorodibenzo-p-dioxin filed 9-16-92; operative 10-16-92 (Register 92, No. 38).
13. Amendment of subsection (b) adding dichloromethane, trichloroethylene and vinyl chloride filed 9-24-92; operative 10-26-92 (Register 92, No. 39).
14. Amendment of subsection (a), new subsections (b)-(b)(1), renumbering of subsection (c) to (b)(2) and amendment, new subsections (c)-(d)(3) filed 10-9-92; operative 11-9-92 (Register 92, No. 41).
15. Effective 10-29-99, allyl chloride and chlorodibromomethane were removed from the list of chemicals known to the State to cause cancer. The no significant risk levels of these chemicals were also removed, effective 10-29-99, from Title 22, CCR, sections 12705(c)(2) and 12705(d)(3) (Register 2001, No. 19).
16. Amendment of subsections (b), (c)(2) and (d)(3) filed 7-18-2002; operative 8-17-2002 (Register 2002, No. 29).
17. Amendment of subsections (a) and (b)(2) and deletion of extraneous subsection (b) designator filed 1-7-2003; operative 2-6-2003 (Register 2003, No. 2).
18. Amendment of subsections (b)(1) and (d)(3) filed 2-25-2003; operative 3-27-2003 (Register 2003, No. 9).
19. Amendment of subsection (b)(1) filed 4-12-2004; operative 5-12-2004 (Register 2004, No. 16).
20. Amendment of subsection (b)(1) filed 6-10-2004; operative 7-10-2004 (Register 2004, No. 24).
21. Amendment of subsection (b)(1) adding "1,2-Dichloropropane" filed 12-23-2004; operative 1-22-2005 (Register 2004, No. 52).
22. Amendment of subsections (b)(1) and (d)(3) filed 8-12-2005; operative 9-11-2005 (Register 2005, No. 32).
23. Change without regulatory effect amending subsection (d)(3) filed 1-30-2007 pursuant to section 100, title 1, California Code of Regulations (Register 2007, No. 5).
24. Effective December 8, 2006, 5 nitro-o-anisidine was removed from the list of chemicals known to cause cancer. This resulted in 5 nitro-o-anisidine and its no significant risk level contained in Section 12705(d)(3) no longer being applicable effective December 8, 2006. This change without regulatory effect removing 5 nitro-o-anisidine from Section 12705(d)(3) was filed 1-30-2007 pursuant to section 100, title 1, California Code of Regulations (Register 2007, No. 5).
25. Amendment of subsection (b)(1) adding "Nitromethane" filed 3-27-2008; operative 4-26-2008 (Register 2008, No. 13).
26. Change without regulatory effect renumbering title 22, section 12705 to title 27, section 25705, including amendment of subsections (b), (d) and (d)(3), filed 6-18-2008 pursuant to section 100, title 1, California Code of Regulations (Register 2008, No. 25).
27. Amendment of subsection (b)(1) filed 8-8-2008; operative 9-7-2008 (Register 2008, No. 32).
28. Amendment of subsection (b)(1) filed 4-7-2009; operative 5-7-2009 (Register 2009, No. 15).
29. Amendment of subsection (b)(1) filed 7-13-2010; operative 8-12-2010 (Register 2010, No. 29).
30. Amendment of subsection (b)(1) filed 1-26-2011; operative 2-25-2011 (Register 2011, No. 4).
31. Amendment of subsection (b)(1) filed 1-26-2011; operative 2-25-2011 (Register 2011, No. 4).
32. Amendment of subsection (b)(1) filed 1-9-2012; operative 2-8-2012 (Register 2012, No. 2).
33. Amendment of subsections (b)(1) and (d)(3) filed 3-15-2012; operative 6-15-2012 pursuant to Government Code section 11343.4(b) (Register 2012, No. 11).
34. Amendment of subsection (c)(2) filed 3-26-2012; operative 4-25-2012 (Register 2012, No. 13).
35. Amendment of subsection (b)(1) filed 6-18-2012; operative 7-18-2012 (Register 2012, No. 25).
36. Repealer of subsection (b)(2) and amendment of Note filed 7-12-2012; operative 8-11-2012 (Register 2012, No. 28).
37. Amendment of subsection (b)(1) adding Tris(1,3-dichloro-2-propyl) phosphate and amendment of Note filed 9-20-2012; operative 10-20-2012 (Register 2012, No. 38).
38. Editorial correction repealing subsection (b)(2) pursuant to 7-12-2012 filing (Register 2012, No. 39).
39. Amendment of subsection (b)(1) adding "Bromoethane" filed 12-17-2012; operative 1-16-2013 (Register 2012, No. 51).
40. Amendment of subsection (b)(1) adding "Diisononyl phthalate (DINP)" filed 2-8-2016; operative 4/1/2016 (Register 2016, No. 7).
41. Amendment of subsection (b)(1) adding "Styrene" filed 5-4-2017; operative 7/1/2017 (Register 2017, No. 18).
42. Amendment of subsection (b)(1) adding "Malathion" filed 2-5-2018; operative 4/1/2018 (Register 2018, No. 6).
43. Amendment of subsection (b)(1) adding "Glyphosate" filed 4-6-2018; operative 7/1/2018 (Register 2018, No. 14).
44. Amendment of subsection (b)(1) adding "Vinylidene chloride" filed 5-9-2018; operative 7-1-2018 (Register 2018, No. 19).
45. Amendment of subsection (b)(1) adding "Bromochloroacetic acid" filed 2-5-2019; operative 4-1-2019 (Register 2019, No. 6).
46. Amendment of subsection (b)(1) adding "Bromodichloroacetic acid" filed 2-5-2019; operative 4/1/2019 (Register 2019, No. 6).
47. Amendment of subsection (b)(1) filed 12-2-2020; operative 4/1/2021 (Register 2020, No. 49).
48. Amendment of subsection (b)(1) adding "Dichloroacetic acid" filed 6-24-2021; operative 10/1/2021 (Register 2021, No. 26).
49. Amendment of subsection (b)(1) adding "Trichloroacetic acid" filed 7-6-2021; operative 10-1-2021 (Register 2021, No. 28). Filing deadline specified in Government Code section 11349.3(a) extended 60 calendar days pursuant to Executive Order N-40-20.
50. Amendment of subsection (b)(1) adding "Dibromoacetic acid" filed 7-6-2021; operative 10/1/2021 (Register 2021, No. 28). Filing deadline specified in Government Code section 11349.3(a)extended 60 calendar days pursuant to Executive Order N-40-20.
51. Amendment of subsection (b)(1) adding "1,3-Dichloropropene" filed 6-13-2022; operative 10/1/2022 (Register 2022, No. 24).