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49 CFR 40.87 : Transportation (§ 1.1 To Parts 1581-1699) — (§ 1.1 To Appendix To Subtitle A) — Office Of The Secretary Of Transportation (§ 1.1 To Appendix To Subtitle A) — Procedures For Transportation Workplace Drug And Alcohol Testing Programs (§ 40.1 To Appendix H To Part 40) — Drug Testing Laboratories (§ 40.81 To § 40.113) — What are the cutoff concentrations for drug tests?

4 Aug 2016

(a) As a laboratory, you must use the cutoff concentrations displayed in the following table for initial and confirmatory drug tests. All cutoff concentrations are expressed in nanograms per milliliter (ng/mL). The table follows:

Initial test analyte Initial test cutoff concentration Confirmatory test analyte Confirmatory test cutoff concentration
Marijuana metabolites 50 ng/mL THCA 1 15 ng/mL.
Cocaine metabolites 150 ng/mL Benzoylecgonine 100 ng/mL.
Opiate metabolites
Codeine/Morphine 2 2000 ng/mL Codeine 2000 ng/mL.
Morphine 2000 ng/mL.
6-Acetylmorphine 10 ng/mL 6-Acetylmorphine 10 ng/mL.
Phencyclidine 25 ng/mL Phencyclidine 25 ng/mL.
Amphetamines 3
AMP/MAMP 4 500 ng/mL Amphetamine 250 ng/mL.
Methamphetamine 5 250 ng/mL.
MDMA 6 500 ng/mL MDMA 250 ng/mL.
MDA 7 250 ng/mL.
MDEA 8 250 ng/mL

1 Delta-9-tetrahydrocannabinol-9-carboxylic acid (THCA).

2 Morphine is the target analyte for codeine/morphine testing.

3 Either a single initial test kit or multiple initial test kits may be used provided the single test kit detects each target analyte independently at the specified cutoff.

4 Methamphetamine is the target analyte for amphetamine/methamphetamine testing.

5 To be reported positive for methamphetamine, a specimen must also contain amphetamine at a concentration equal to or greater than 100 ng/mL.

6 Methylenedioxymethamphetamine (MDMA).

7 Methylenedioxyamphetamine (MDA).

8 Methylenedioxyethylamphetamine (MDEA).

(b) On an initial drug test, you must report a result below the cutoff concentration as negative. If the result is at or above the cutoff concentration, you must conduct a confirmation test.

(c) On a confirmation drug test, you must report a result below the cutoff concentration as negative and a result at or above the cutoff concentration as confirmed positive.

(d) You must report quantitative values for morphine or codeine at 15,000 ng/mL or above.

49 CFR 40.87
[65 FR 79526, Dec. 19, 2000, as amended at 75 FR 49862, Aug. 16, 2010; 77 FR 26473, May 4, 2012]